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nusA [2017-07-27 11:43:15]
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nusA [2017-07-27 11:43:15]

transcription termination factor of RNA polymerase
Locus
BSU16600
Isoelectric point
4.58
Molecular weight
41.57 kDa
Protein length
371 aa Sequence Blast
Gene length
1113 bp Sequence Blast
Function
transcription
Product
transcription termination factor
Essential
yes
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Information processing → RNA synthesis and degradation → Transcription → Transcription elongation/ termination
  • Groups of genes → Essential genes

    • Gene

    Coordinates
    1,732,281 → 1,733,396

    Phenotypes of a mutant

  • essential PubMed

    • The protein

    Catalyzed reaction/ biological activity

  • stimulates transcription termination at weak intrinsic terminators Reference

    • Protein family

  • nusA family (according to Swiss-Prot)

    • Structure

  • 1HH2 (from Thermotoga maritima, 51% identity) PubMed

    • Expression and Regulation

    Operons

    Genes
    ylxS-nusA-ylxR-rplGA-infB-ylxP-rbfA
    Description
    PubMed

    Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigB: sigma factor, PubMed, in SigB regulon

    • Regulatory mechanism

  • stringent response: negative regulation, in stringent response
  • NusA: attenuation, NusA stimulates termination [Reference|http://www.nature.com/articles/nmicrobiol20157], in NusA regulon

    • Regulation

  • autoregulation NusA reference
  • induced by glucose PubMed
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    Biological materials

    Two-hybrid system

  • B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Fabian Commichau's lab

    • References

    Reviews

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    Original publications

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